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Additional file

Purple areas represent the estimated density of the hub distributions (bottlenecks) and blue areas represent non-hub (non-bottlenecks) areas. (A) Comparison of the estimated density of distribution of miRNAs numbers between hubs (bottlenecks) and non-hubs (non-bottlenecks). (B) Comparison of the estimated density of the distribution of virus types between hubs (bottlenecks) and non-hubs (non-bo...

Additional file 6

Assembly and super scaffolding with multiple genera. We examined experiments from 16 different genera to determine if the results seen for the Tribolium castaneum genome are typical for other genomes as well. The T. castaneum genome map N50 was found to be in the high end of the probability density distribution (Additional file 6; Figure 1). The same is true for the Tcas5.0 draft sequence assem...

Additional file 5.xlsx

position -4 C50 C49 C48 C47 C46 C45 C44 C43 C42 C41 C40 C39 C38 C37 C36 C35 C34 C33 C32 C31 C30 C29 C28 C27 C26 C25 C24 C23 C22 C21 C20 C19 C18 C17 C16 C15 C14 C13 C12 C11 C10 C9 C8 C7 C6 C5 C4 C3 C2 C1 C0 C-index SD P-value mark A 5 7 9 1 8 4 6 2 1 4 8 7 6 9 3 4 3 7 15 10 6 6 9 3 2 5 3 6 8 9 6 3 5 7 7 10 4 7 7 8 5 5 8 2 2 3 1 2 5 5 9 0.618 0.317 8.27E-03 n.s. A C 3 1 2 0 2 3 3 1 1 2 1 7 4 9 1 ...

Additional file 7

iPAINT: a general approach tailored to image the topology of interfaces with nanometer resolution† †Electronic supplementary information (ESI) available: Fig. S1–S8. See DOI: 10.1039/c6nr00445h Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

Understanding interfacial phenomena in soft materials such as wetting, colloidal stability, coalescence, and friction warrants non-invasive imaging with nanometer resolution. Super-resolution microscopy has emerged as an attractive method to visualize nanostructures labeled covalently with fluorescent tags, but this is not amenable to all interfaces. Inspired by PAINT we developed a simple and ...

Membrane stiffness is modified by integral membrane proteins† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sm01186a Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

The ease with which a cell membrane can bend and deform is important for a wide range of biological functions. Peripheral proteins that induce curvature in membranes (e.g. BAR domains) have been studied for a number of years. Little is known, however, about the effect of integral membrane proteins on the stiffness of a membrane (characterised by the bending rigidity, Kc). We demonstrate by comp...